WebConsistent with potential oxidative stress due to activated oxidative phosphorylation, DNA damage-related signals (e.g., the up-regulated hsa03420 nucleotide excision repair [FDR, 1.14E-04] and hsa03410 base excision repair [FDR, 2.71E-04] pathways) were observed. WebAug 13, 2024 · Aim: To develop an oxidative phosphorylation (OXPHOS)-related gene signature of lung adenocarcinoma (LUAD). Materials & methods: We split The Cancer Genome Atlas LUAD cohort into a training set and a test set; we used the least absolute shrinkage and selection operator Cox method to structure the OXPHOS-related prognostic …
PGC-1α-responsive genes involved in oxidative phosphorylation …
WebApr 23, 2024 · In this study, we show in prostate cancer cells that arginine acts as an epigenetic regulator to modulate histone acetylation, leading to global upregulation of nuclear-encoded oxidative phosphorylation (OXPHOS) genes. TEAD4 is retained in the nucleus by arginine, enhancing its recruitment to the promoter/enhancer regions of … WebJan 12, 2016 · We obtained the gene-level results (from VEGAS) for all OXPHOS genes, and tabulated the number of genes from the pathway in the top 1%, 5%, and 10% of all genes. We then generated 1,000 gene sets of the same length, sampling randomly from all gene level results from VEGAS (increased to 10,000 permutations for p < 0.05). We calculated ... hammond 2023
Oxidative Phosphorylation - an overview ScienceDirect Topics
WebThe expression of OXPHOS gene set was reported to be regulated by peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α) in some other tissues, which serves as a transcriptional coactivator. ... Four pathways, including oxidative phosphorylation, Alzheimer’s, Parkinson’s, and Huntington’s diseases were significantly ... WebOxidative phosphorylation (OXPHOS) is a metabolic pathway that takes place within those organelles and consists in a series of redox reactions that drive a proton efflux through the mitochondrial inner membrane from the matrix to the intermembrane space. From:Mitochondrial Intoxication, 2024 Related terms: Adenosine Triphosphate … WebOxidative phosphorylation is linked to a process known as electron transport (Figure 5.14). The electron transport system, located in the inner mitochondrial membrane, transfers electrons donated by the reduced electron carriers NADH and FADH2 (obtained from glycolysis, the citric acid cycle or fatty acid oxidation) through a series of ... hammond 24x24 stainless steel